Solid-State Mixture Identification of Crystal Indomethacin by Spectroscopy Comparison with Thermal Analysis

T. B. Sundaresan

Title:
Solid-State Mixture Identification of Crystal Indomethacin by Spectroscopy Comparison with Thermal Analysis

Authors:
T. B. Sundaresan
DOI:
https://doi.org/10.31142/ijtsrd18583

Cite This Article :

T. B. Sundaresan "Solid-State Mixture Identification of Crystal Indomethacin by Spectroscopy Comparison with Thermal Analysis" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-6, October 2018, pp.626-630, URL: https://www.ijtsrd.com/papers/ijtsrd18583.pdf

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Abstract :
This research investigates Raman spectroscopy as a quick and reliable method to quantify the alpha (a) and gamma (?) polymorphic forms of indomethacin compared to differential scanning calorimetry (DSC). Binary mixtures with different ratios of a and ? indomethacin were prepared and analyzed by Raman and DSC. The Raman method was found to be more reliable and superior compared to DSC. The partial conversion of the alpha to gamma polymorphic form during the DSC measurement was the major limitation for the use of full DSC as a quantitative method and resulted in difference between the calculated and measured enthalpy of both polymorphic forms.

Keywords :
alpha, gamma, raman spectroscopy, differential scanning calorimetry (DSC).

Publication Details:

Unique Identification Number : IJTSRD18583

Published In : Volume-2 | Issue-6, October 2018

Page Number(s) : 626-630

Publisher Name : IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470

Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

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